TMG Supplements: Why Biohackers Can’t Get Enough

Struggling with low energy, brain fog, or trouble recovering from workouts? You’re not alone, and TMG supplements might be part of the solution. Short for trimethylglycine, TMG is making waves in the biohacking world for its role in supporting healthy methylation, reducing homocysteine levels, and optimizing cellular function. 

Whether you heard it mentioned on a podcast or saw it in a health forum, there’s a reason it’s becoming a go-to for people looking to fine-tune their health. TMG supports foundational pathways in the body tied to everything from cardiovascular health to brain function. 

In this post, we’re breaking down what TMG supplements are, how they work, and who might actually benefit from taking them. For more insights into the latest biohacking tools, check out the episode below from the Women Want Strong Men podcast. But first, let’s dive in. 

What Are TMG Supplements?

Let’s start with the basics. TMG, also known as betaine, is a compound that naturally occurs in foods like beets, spinach, and whole grains. In supplement form, it’s far more concentrated and often used for its ability to support the body’s methylation cycle—a biochemical process involved in detoxification, DNA repair, neurotransmitter production, and more.

TMG acts as a methyl donor, which means it provides a methyl group (a carbon atom bonded to three hydrogen atoms) that your body needs to run these critical processes. If you’re someone with a sluggish methylation cycle, TMG can help pick up the slack.

What Does TMG Do in the Body?

You might be surprised how many systems in your body rely on methylation to run smoothly. One of TMG’s biggest jobs is converting homocysteine—a potentially harmful amino acid—into methionine, which is an essential building block for protein synthesis and other vital functions.

Lowering homocysteine levels is a big deal, especially when it comes to protecting cardiovascular health. Elevated homocysteine has been associated with increased risk for heart disease, stroke, and cognitive decline. 

TMG helps regulate homocysteine levels, which is why it’s become a popular tool for longevity and prevention.

In addition, TMG supports liver detoxification, energy production, fat metabolism, and even mood regulation. Some people notice improved focus and less brain fog when they get their methylation pathways moving, especially when TMG is paired with supportive nutrients like sublingual B12 and methylated folate.

Benefits of TMG Supplements

So, what does TMG actually do for you? If you’re juggling fatigue, sluggish workouts, or wondering why your mood’s been off lately, it could be tied to poor methylation. That’s where TMG might come in. Here’s how it could help in real life:

• Cardiovascular health – By reducing homocysteine levels, TMG may help support healthy arteries and blood pressure.
• Liver support – TMG aids in phase II liver detoxification, which can be especially helpful if you drink alcohol or are exposed to environmental toxins.
• Energy and metabolism – Proper methylation boosts mitochondrial function, which is critical for sustained energy and fat metabolism.
• Mood and cognition – Because methylation impacts neurotransmitters, TMG may support a more stable mood, mental clarity, and focus.
• Athletic performance – Some research suggests TMG may aid muscle recovery and endurance, making it a potential tool for athletes and active individuals.

These benefits aren’t guaranteed overnight. But for many people, consistent supplementation (especially when combined with other lifestyle strategies) can yield noticeable improvements.

Let’s Talk About Methylation (& Why It Matters)

Think of methylation as your body’s behind-the-scenes maintenance crew. It helps clear out toxins, repair DNA, recycle hormones, and regulate gene expression—but not everyone has an efficient methylation system.

Genetic variations like an MTHFR mutation can impair how well your body donates and recycles methyl groups. By donating a methyl group to homocysteine (and converting it into methionine), TMG gives your system an extra hand.

If you’ve ever had labs done and noticed high homocysteine levels, or you’ve been told you have an MTHFR mutation, adding TMG may help rebalance your system.

Do You Need a TMG Supplement?

Not everyone needs to rush out and buy TMG, but there are certain signs and situations that suggest it might be helpful for you, such as the following:

• You’ve tested high for homocysteine.
• You have an MTHFR mutation.
• You regularly experience fatigue, brain fog, mood swings, or poor detox.
• You’re focused on anti-aging, cardiovascular health, or cellular performance.

Many biohackers love TMG because it targets the root cause behind symptoms. Instead of masking fatigue or brain fog with more caffeine, it supports the pathways that keep your cells functioning properly. If you’re someone who likes to test and track, markers like homocysteine or DNA methylation profiles can help you see if it’s actually working.

Still, supplements aren’t one-size-fits-all. If you’re already taking a B-complex or multivitamin that includes methyl donors, adding TMG might not be necessary. It could even throw off your balance. That’s why we recommend speaking with a healthcare provider who can guide your treatment plan based on your labs and symptoms.

What are the Side Effects of TMG?

For most people, TMG is well tolerated. But like any supplement, it’s important to be aware of potential reactions. At high doses, some people report mild GI discomfort and/or increased body odor (due to a byproduct called trimethylamine).

That’s why we recommend starting low—around 500 mg per day—and increasing only if needed. It also helps to take TMG alongside cofactors like methylated B12 and folate to support balanced methylation. Without these, your body might struggle to use TMG efficiently.

How to Choose a TMG Supplement

As with any supplement, quality matters. Look for products labeled as trimethylglycine (not betaine HCl, which is a different form used for digestion). Choose a brand that prioritizes purity, transparency, and third-party testing. Medical-grade supplements are typically your safest bet for avoiding fillers, contaminants, or under-dosed ingredients.

Standard doses range from 500 mg to 2000 mg daily, but what’s right for you depends on your goals and nutrient status. At Victory Men’s Health, we help our patients optimize their health from the inside out with a customized treatment plan tailored to their lab results and needs.

TMG can be a smart addition to a well-rounded supplement strategy, but it works best when used as part of a bigger picture. Whether your goal is boosting energy, lowering homocysteine, or simply feeling better in your body, we’re here to support your journey. 

Ready to Take Charge of Your Health?

TMG supplements are just one of the many tools that can help support better energy, sharper focus, and long-term health—especially when paired with the right testing and support. At Victory Men’s Health, we work with individuals across all stages of their health journey. 

If you’re struggling with low testosterone, weight gain, ED, brain fog, chronic fatigue, or other symptoms, we’ll help you determine the root cause and map out a plan that gets results. Ready to take charge of your health? Book a consultation today and let’s build a strategy that works.