Statins vs. Estradiol: Which is Better for Heart Health?

Young tanned man with hand on chest feeling heart pain - statins vs estradiol for heart health

It’s no secret that cardiovascular disease remains a leading concern for men and women. Statins have long been the first choice to manage cholesterol and lower the risk of heart disease. Now, there’s a new contender: hormone therapy, specifically with estradiol. So, when it comes to statins vs. estradiol, which is better?

Today, we’re exploring what each option offers, how they’re different, and which one might be the right choice for you. If you’re worried about your cardiovascular health, reach out to schedule a consultation for a heart health screening with one of our providers. 

On an episode of the Women Want Strong Men podcast, we sat down with Dr. John Carrozzella to discuss all things estradiol and its cardio-protective effects. Check out the full episode below, then keep reading to learn more. 

What Are Statins?

Statins are a type of drug used to lower LDL cholesterol—the kind that contributes to plaque buildup in your arteries. This buildup can restrict blood flow, increasing the risk of heart attack or stroke. 

Because they’re effective at reducing LDL cholesterol, statins have become one of the most widely prescribed cholesterol medications.

While statins do help lower cholesterol, their overall effectiveness in reducing heart disease risk can be limited. Research shows they’re beneficial for high-risk patients, but the actual risk reduction is relatively modest—about 4%.

For many people, especially those who don’t already have heart disease, statins don’t always produce the results we’d hope for. Plus, they come with some side effects that, for some men, can be fairly uncomfortable. It’s also important to note that while statins mainly target cholesterol, that’s not the only piece of the heart health puzzle.

What is Estradiol?

Estradiol is a form of estrogen. While it’s typically associated with women’s health, it’s also crucial for men’s health—especially as you age. Estradiol plays a role in many of our bodily functions, including keeping our hearts in good shape. Unlike statins, which focus only on lowering cholesterol, estradiol supports heart health on multiple fronts.

Estradiol works differently than statins by reducing inflammation, improving blood flow, and helping to keep the artery walls strong and clear. 

As men and women age, our hormone levels naturally decline. In women, this drop is particularly steep after menopause, which coincides with a big rise in heart disease risk. Men experience a gradual decline in estradiol as well, and it can impact heart health over time. 

Statins vs. Estradiol: Which is Better for Heart Health?

So, let’s get down to the main question: if both statins and estradiol can help with heart health, how do they compare? Here’s a closer look at how each works and what you can expect.

Mechanisms of Action

Statins primarily work by lowering LDL cholesterol in your blood, which helps to reduce plaque buildup in arteries. This can lower the chance of blockages, which can lead to heart attacks or strokes. But beyond cholesterol, statins don’t address other causes of heart disease, like inflammation or blood vessel health.

Estradiol has a broader effect on heart health. In addition to reducing cholesterol, it also reduces inflammation, improves blood flow, and protects blood vessels. Think of it as a multi-layered approach—estradiol targets several heart disease risk factors at once, not just one.

Research Insights

The evidence for both treatments is compelling but also tells different stories. Statins are effective in lowering cholesterol, which can help reduce the risk of heart issues, especially for people already at high risk. But if we’re talking about overall heart protection and vitality, estradiol has a lot going for it. 

Studies suggest that estradiol may lower overall mortality rates and offer broader protection for the heart, brain, and even bones. For men and women interested in not just surviving but thriving as they age, estradiol is proving to be a valuable ally.

Long-Term Impact

Long-term, the effects of these treatments can vary quite a bit. While statins effectively lower LDL, they could be a lifelong commitment—it’s generally not recommended to stop them without medical guidance. Suddenly discontinuing statins without talking to your healthcare provider could raise your risk of heart attack or stroke, even if you don’t feel immediate symptoms. 

Estradiol, on the other hand, may offer additional benefits beyond heart health. It can support cognitive health, protect bone density, and contribute to overall vitality. In other words, statins can be an effective option for managing cholesterol, but estradiol offers a more well-rounded approach to healthy aging.

Side Effects of Statins vs. Estradiol

As with any medication or hormone therapy, it’s important to consider the potential side effects before making a decision. Let’s take a look at what you might expect with statins vs. estradiol.

Statin Side Effects

  • Muscle Pain: Some men report muscle pain or weakness, which can impact mobility and day-to-day life.
  • Cognitive Issues: There’s some evidence suggesting that statins may affect memory or cognitive function in certain people.
  • Risk of Diabetes: Statins may increase the likelihood of developing type 2 diabetes, particularly in people already at risk.

Estradiol Considerations

  • Hormone Balance Concerns: Hormone therapy is safe when monitored by a knowledgeable healthcare provider, but finding the right balance is key.
  • Cardiovascular Benefits: For women, estradiol levels drop to near zero after menopause, which significantly increases the risk of cardiovascular disease. Replacing estradiol can help mitigate this risk. Similarly, in men, testosterone replacement therapy leads to a natural conversion to estradiol, which provides heart-protective effects.
  • Minimal Cancer Risk: Studies on bioidentical estradiol show a very low cancer risk, and in some cases, estradiol may even reduce certain cancer risks. Your provider will evaluate individual risk factors to find the best approach for you.

When to See a Doctor for Heart Health

So, when should you consider talking to a healthcare provider about your heart health? Here are a few signs that might mean it’s time to explore your options.

  • High Cholesterol Levels: If you’ve been told your LDL cholesterol is high, it’s a good idea to ask your doctor about actions you can take to get it in check.
  • Family History of Heart Disease: A family history of heart disease can raise your own risk, so it’s smart to be proactive.
  • Menopausal Symptoms (for Women): For women entering menopause, a significant drop in estradiol levels can increase heart disease risk, making it a good time to talk to a provider about your options.
  • Feeling Constantly Drained: If you’re frequently tired or feeling a decline in vitality, it could be tied to hormone changes affecting your cardiovascular health.

Take Charge of Your Heart Health Today

Statins and estradiol offer unique benefits for heart health, each bringing something different to the table. Statins can lower LDL cholesterol, which is valuable for certain people, particularly those who have already experienced an event such as a heart attack or stroke. 

But if you’re looking for a more comprehensive approach that also supports energy, strength, and overall vitality, hormone replacement therapy is a powerful option. At Victory Men’s Health, we know that heart health isn’t one-size-fits-all. That’s why we take a personalized approach tailored to your unique needs. 


Our team will work with you to build a treatment plan that prioritizes your health, vitality, and longevity. Ready to make your heart health a priority? Contact us today to book a consultation and begin your journey to feeling stronger and living better.

Do Statins Lower Libido? 

Statins are commonly prescribed to individuals who need help managing their cholesterol. These medications can be effective in reducing cholesterol levels, but many of our male patients wonder if statins lower libido in the process.

At Victory Men’s Health, we understand that your sexual health and overall well-being go hand-in-hand. Whether you’re looking for answers about your new prescription, alternative methods of reducing cholesterol, or ways to boost your libido, we’re answering it all in today’s blog post. 

What are Statins?

Statins’ role is to reduce the levels of cholesterol in your bloodstream by blocking a liver enzyme called HMG-CoA reductase, which is responsible for producing cholesterol. By inhibiting it, statins can help reduce the levels of low-density lipoprotein (LDL) cholesterol—also known as “bad” cholesterol. 

Statins are typically prescribed for men who are at risk of cardiovascular disease, heart attacks, or strokes due to high cholesterol.

If you’ve been diagnosed with high cholesterol and lifestyle changes haven’t been enough to lower your levels, your doctor may recommend statins to help protect your heart. While these drugs can be effective in reducing cardiovascular risk, some men worry about how they might affect their testosterone and libido. 

What’s the Connection Between Statins and Testosterone Levels?

Testosterone is crucial for men’s overall health. It plays a role in everything from muscle mass and energy levels to libido and sexual function. Because cholesterol is a building block for testosterone, there’s a common concern that lowering cholesterol too much might also lower testosterone levels.

However, research on this is mixed. Some studies suggest that statins could slightly reduce testosterone levels, while others show no significant effect. It’s worth noting that the impact of statins on testosterone levels likely varies from person to person, depending on factors like age, overall health, and dosage. 

If you’re concerned about your testosterone levels while taking statins, it’s always a good idea to monitor them with regular blood tests. At Victory Men’s Health, we can help you track your testosterone and make adjustments as needed to keep you feeling your best.

Do Statins Cause Erectile Dysfunction (ED)?

One of the biggest concerns for men on statins is whether these medications can cause ED. Again, the research isn’t entirely clear-cut. Some studies suggest that statins may have a neutral or even positive effect on erectile function, possibly due to their role in improving blood vessel health. 

Better blood flow is key for achieving and maintaining erections, so it makes sense that lowering cholesterol might improve vascular function and, in turn, erectile performance. On the flip side, some men report experiencing ED after starting statins. This could be related to the potential impact on testosterone levels, or it might simply be a side effect in a small number of cases. 

If you notice issues with ED after starting statins, it’s important to talk to a healthcare provider who specializes in men’s sexual health and understands the full picture. They may recommend adjusting your medications or exploring treatments like testosterone replacement therapy (TRT).

Does High Cholesterol Affect Libido?

High cholesterol can damage your blood vessels, limiting blood flow throughout your body—including to your penis. When blood flow is restricted, it becomes harder to achieve and maintain an erection, which can naturally dampen your sex drive.

Additionally, high levels of certain types of cholesterol particles, along with high blood pressure and other inflammatory conditions, lead to the buildup of plaque in the arteries, a condition known as atherosclerosis. This can further restrict blood flow and contribute to both ED and reduced libido. 

So, even if statins have some potential side effects, not addressing cardiovascular risk factors can also impact on your sexual health.

When to Get Tested for High Cholesterol

do statins lower libido - man walking into Victory Men's Health clinic

Knowing when to test for high cholesterol is an important part of staying on top of your heart health. While regular doctor visits often include a basic lipid panel measuring triglycerides, HDL, LDL, and total cholesterol, this standard test might not capture the full picture—especially if you’re considering options like statins.

At Victory Men’s Health, we offer advanced cardiovascular testing for individuals who want a deeper look.

Our advanced lipid profile goes beyond standard cholesterol measures, and our Carotid Intima-Media Thickness (CIMT) test is a quick, non-invasive ultrasound that detects early signs of atherosclerosis by assessing the thickness of your carotid artery walls. These tests provide valuable insights, helping you and your provider make the best decisions for managing cholesterol and protecting your heart health.

Whether you’re considering lifestyle changes, statins, or other treatments, knowing your exact cardiovascular profile can help you take a more personalized approach to your well-being. Schedule a consultation with our team if you’re interested in learning more about our advanced cardiovascular testing options. 

Can I Lower Cholesterol Without Statins?

For some men, the idea of taking statins doesn’t sit well—especially if they’re worried about side effects like reduced sex drive or muscular aches. The good news is that there are several natural ways to lower your cholesterol without medication, and these methods won’t cause those negative side effects.

Here are some ways to lower your cholesterol without lowering your libido: 

  1. Change Your Diet
  2. Exercise Regularly
  3. Quit Smoking & Limit Alcohol
  4. Try Supplements

Change Your Diet

Eating heart-healthy foods can make a big difference in your cholesterol levels. Focus on foods rich in omega-3 fatty acids (like fish and flaxseeds), high-fiber foods (like oats, vegetables, beans, and fruits), and healthy fats (like olive oil and avocado). Cutting back on added sugars, ultra-processed foods, and fast food can also help keep your cholesterol in check.

Exercise Regularly

Regular exercise is one of the best ways to improve your cholesterol levels and boost your overall health. Aim for at least 30 minutes of physical activity most days of the week. Strength training, in particular, can help maintain muscle mass and boost testosterone levels, so it’s a win-win for your health and your libido.

Quit Smoking and Limit Alcohol

Both smoking and excessive alcohol consumption can raise your cholesterol and contribute to ED. If you’re looking for ways to improve both your heart health and your sex life, quitting smoking and limiting alcohol is a great place to start.

Try Supplements

Certain supplements, such as plant sterols, fish oil, CoQ10, berberine, bergamot, aged garlic, and soluble fiber (like psyllium), have been shown to help lower cholesterol. Always consult with a healthcare provider before starting new supplements, but these could be a natural way to support your heart health without affecting your libido.

Ways to Boost Testosterone Levels for Better Libido

If you’re concerned that statins—or even just age—are affecting your testosterone levels, there are several ways you can naturally boost your T levels. 

Strength Training

Lifting weights and engaging in resistance exercises can boost testosterone levels. The more muscle mass you build, the more your body produces testosterone, which can also improve your libido and overall vitality.

Sleep

Getting enough sleep is crucial for maintaining healthy testosterone levels. Aim for 7-9 hours of quality sleep each night, as your body produces the most testosterone during deep sleep.

Diet

Certain foods are known to support testosterone production—like eggs, lean protein, nuts, and foods rich in zinc and vitamin D. Keeping a balanced diet can help you maintain optimal testosterone levels.

Stress Management

Chronic stress increases cortisol levels, which can negatively impact testosterone production. Finding ways to manage stress—whether through meditation, exercise, or relaxation techniques—can help keep your testosterone levels healthy.

The Most Effective Way to Boost Testosterone and Libido

While lifestyle changes can help support healthy testosterone levels, sometimes they’re not enough. That’s where Testosterone Replacement Therapy (TRT) comes in. We offer personalized options that can help bring your testosterone back to optimal levels, enhancing your energy, libido, and overall quality of life.

Here are the TRT options we offer:

  • Injections – Testosterone injections are administered by a healthcare provider each week, delivering a controlled dose of testosterone directly into your bloodstream. This option provides fast, effective results for men who need a boost in their testosterone levels.
  • Creams – Applied topically to the skin in an area directed by your provider, testosterone creams are absorbed into the body. They offer a convenient, daily method to maintain testosterone levels without the need for injections.
  • Pellets – Testosterone pellets are small implants placed under the skin that release a steady dose of testosterone over 4-6 months. This option is great for men looking for long-term, low-maintenance therapy.

At Victory Men’s Health, we’ll work with you to determine the best TRT method for your lifestyle and health goals. Our team is dedicated to helping you feel your best, with personalized care and support every step of the way.

Begin Your Journey to Better Sexual Health

If you’re concerned about how statins or high cholesterol might be affecting your libido or testosterone levels, we’re here to help. Our team specializes in men’s health and can guide you through the best options for lowering your cholesterol while maintaining your sexual health. 


Whether it’s adjusting your medications or starting testosterone replacement therapy, we’re ready to help you regain control of your health and vitality. Contact us today to book a consultation, and let’s begin your journey to better sexual health.