Tag: methylation

Methylated Multivitamins: Should You Make the Switch?

Posted on by AmyADMIN

What if the reason your supplements aren’t working has nothing to do with the brand and everything to do with your genes? For many men, taking a standard multivitamin every morning is just part of the routine. But if you’re still feeling drained or foggy, there’s a good chance your body isn’t absorbing what you’re giving it—and that’s where methylated multivitamins can help.

These upgraded formulas are designed for better absorption and real results, especially if you’ve got an MTHFR gene mutation affecting how your body processes nutrients. In this guide, we’ll break down what methylated vitamins are, how they work, and whether making the switch is the right call for you. Let’s dive in. 

What Are Methylated Vitamins?

Methylated vitamins are the pre-activated forms of certain nutrients—mainly B vitamins like B12 and folate—that your body can use right away.

Normally, your body has to convert standard vitamins into their active form, but not everyone’s body does that well. That conversion process is called methylation, and it affects everything from your mood and energy to your ability to detox and fight inflammation.

If you have issues with methylation (which we’ll get into), taking regular folic acid or B12 might not do much for you. However, methylated versions like methylfolate and methylcobalamin skip that step and deliver the active form your body actually needs.

What’s the MTHFR Gene and Why Does It Matter?

This is the part no one explains at the supplement shop, but it’s key to understanding why methylated vitamins even exist. MTHFR (short for methylenetetrahydrofolate reductase) is a gene that controls an enzyme involved in processing folate and supporting detox pathways. Up to 40% of people have a variation in this gene that slows down that process.

If you have one of these MTHFR mutations, your body may struggle to:

  • Convert folic acid into usable folate
  • Make enough glutathione (your body’s master antioxidant)
  • Regulate homocysteine, an inflammation marker linked to heart disease

We sat down with Dr. Katie Rybeck on an episode of the Women Want Strong Men podcast to recap the key takeaways from the 2024 WorldLink 9th Annual Academic Summit. During our chat, Dr. Rybeck shared that people with MTHFR mutations tend to have higher inflammation, lower bone density, and poor B vitamin status across the board. 

That’s where methylated vitamins can make a real difference.

Methylated Multivitamins vs. Regular Ones: What’s the Difference?

“Are multivitamins really helpful? Are methylated multivitamins actually different from regular multivitamins?” We hear these questions a lot, and the answer is yes! The key difference lies in the form of the nutrients inside. Your body has to convert most vitamins into a usable form, but some people aren’t very good at that thanks to genetics they can’t control—like MTHFR. 

Methylated multivitamins give you the already-converted forms your body can absorb and use more efficiently, which can make a huge difference in how you feel. Here’s a quick breakdown:

  • Regular multivitamins often use cheaper, synthetic forms like folic acid (instead of folate) and cyanocobalamin (instead of methylcobalamin).
  • Methylated multivitamins use forms your body can absorb immediately, like 5-MTHF for folate and methylcobalamin for B12.

If your body has trouble converting those nutrients (which MTHFR mutations interfere with), regular multivitamins may do little or nothing for you. On the flip side, a methylated vitamin delivers the form your body is ready to use.

What are the Benefits of Methylated Multivitamins?

No one goes searching for the next best multivitamins just for fun—they do it to feel better. That’s the real draw of methylated multivitamins: they help your body actually use the nutrients you’re taking. If you’ve been taking supplements for years with little to show for it, switching to a methylated formula might be the change that finally moves the needle.

And if you’ve got a genetic mutation like MTHFR or struggle with fatigue, brain fog, or mood swings? This could be the upgrade your system has been silently begging for. Here’s what you can expect within a few weeks of switching to methylated multivitamins:

  • More stable, all-day energy without the highs and crashes
  • Improved focus and mental clarity, especially during stressful days
  • Better mood and emotional resilience, thanks to enhanced neurotransmitter support
  • Lower inflammation and better detox support through improved methylation
  • Healthier heart and blood vessels, especially if you’ve had high homocysteine levels
  • Support for healthy aging, cognitive function, and immune health
  • Fewer nutrient deficiencies, especially in B12, folate, and other critical vitamins

If you’ve been taking regular multivitamins and still feel like something’s missing, this could be the answer.

Who Should Take a Methylated Multivitamin?

If you’re feeling run down, foggy, or just not getting results from your current supplements, a methylated multivitamin might be worth a closer look. It’s especially helpful for people with trouble processing B vitamins—something we see often in people with MTHFR gene mutations. 

Not sure if that’s you? The only way to know for sure is to test. But if you suspect something’s off, we recommend consulting your healthcare provider to see if making the switch is a good move. Common candidates for methylated multivitamins include:

  • People with MTHFR mutations
  • Anyone with chronic fatigue, brain fog, or mood issues
  • Those with high inflammation or poor detox function
  • People not seeing benefits from standard vitamins
  • Those with low B12, folate, or high homocysteine levels on labs

We offer a variety of advanced health screenings, like MTHFR, homocysteine, and micronutrient testing, to help you figure out exactly what your body needs and how to get it. 

What are the Side Effects of Methylated Multivitamins?

Methylated vitamins are safe for most people, even if you don’t have an MTHFR mutation. But like anything in the supplement world, balance matters. In rare cases, too much methylation support (especially if you take multiple B-complex supplements or high-dose formulas) can cause unwanted symptoms like:

  • Anxiety or restlessness
  • Headaches
  • Irritability

This typically only happens with mega-doses or poor combinations. That’s why we recommend working closely with a provider before making any changes to your supplement regimen. 

Which Methylated Multivitamin Should You Take?

All multivitamins are not created equal, and that’s especially true when it comes to methylation support. You want something that includes the active forms of B vitamins—not the cheap, synthetic stuff you’ll find in most drugstore brands. 

The best methylated vitamins are clean, balanced, and designed for bioavailability. At Victory Men’s Health, we can help you choose a formula that fits your needs and your health goals.

Look for:

  • Methylfolate (5-MTHF)
  • Methylcobalamin (B12)
  • P-5-P (active B6)
  • Riboflavin-5-phosphate (active B2)
  • Supporting nutrients like magnesium and zinc

Avoid:

  • Folic acid
  • Cyanocobalamin
  • Artificial dyes or unnecessary fillers

Questions We Get About Methylated Multivitamins

Can I Take a Methylated Multivitamin Without an MTHFR Mutation?

Yes! Methylated vitamins are generally safe and effective for most people. Even without the mutation, your body may still benefit from easier absorption and better nutrient delivery.

Is Folic Acid Bad for You?

Not inherently, but if you have trouble converting it (which is common), folic acid can build up in the body and become problematic over time. Methylfolate is often a safer bet, but it’s best to discuss with your healthcare provider first. 

How Do I Know if I Have an MTHFR Mutation?

Genetic testing is the most accurate way to find out. With that said, you can also look for clues in your bloodwork, like high homocysteine or low B12/folate. We offer both types of testing in our Missouri and Illinois clinics. 

Can Methylated Vitamins Help with Energy and Mood?

They can, especially if you’ve been running low on active B vitamins. These nutrients play a huge role in neurotransmitters, detox, and energy production, so better absorption can make a real difference.

Are Methylated Multivitamins More Expensive?

Usually, yes—but they’re still very affordable. Our methylated multivitamin and sublingual B12 are great examples: they’re made with high-quality, bioavailable ingredients your body can actually use, which means better results and less wasted money. 

And when it comes to B12, taking it as a dissolvable tablet under the tongue (sublingual) helps bypass common absorption issues in the gut—making it a smarter, more effective choice for many people.

Final Thoughts: Should You Make the Switch?

While not everyone needs methylated multivitamins, it can be a game-changer for those who do. Whether you’re dealing with low energy, brain fog, or just want to optimize your long-term health, switching to a form your body can efficiently use is a smart move.

At Victory Men’s Health, we take the guesswork out of wellness. Our team uses advanced lab testing, genetic insights, and real-world experience to design treatment plans that work for you. From optimizing your nutrient levels to fine-tuning hormones, we’re here to help you feel stronger, think clearer, and live with more vitality every day.

Ready to optimize your health? Contact us today to schedule a consultation and get back to feeling like the best version of yourself.

Methylation Testing 101: Is it the Key to Healthy Aging?

Posted on by AmyADMIN

We’re always looking for cutting-edge ways to help you live better. Recently, we sat down with functional medicine expert Umaro Cadogan on the Women Want Strong Men podcast. He gave us incredible insights into methylation testing—a powerful tool that helps you understand your body on a deeper level for healthier aging.

If you’ve never heard of methylation or wonder if genetic testing could benefit you, you’re in the right place. In this post, we’ll break down what methylation is, why it matters, and how a simple gene test can help you age well and live your best life. Check out the full episode below and keep reading on to learn more. 

What is Methylation and Why is it Important?

Methylation might seem complex, and in many ways it is—because numerous nutrients need to work together in a biochemical reaction for the proper outcome.

This process involves adding tiny molecules called methyl groups to DNA, proteins, and hormones, which is crucial for supporting essential bodily functions. If even one aspect of methylation is off, it can create a chain reaction of problems. That’s the beauty of methylation testing—it helps identify the root cause of imbalances if there’s a genetic mutation or SNP (Single Nucleotide Polymorphism). 

Think of methylation like an on/off light switch for the processes in your body.

Bodily Processes Impacted by Methylation

Umaro said it best in our podcast episode: “Methylation is everywhere. It’s crucial for everything from brainpower to immune strength.” Your body relies on methylation to stay balanced and function properly, especially as you age. Let’s take a look at some of the processes methylation impacts.

  • Detoxification: It helps your body flush out toxins and harmful substances.
  • DNA Repair and Gene Regulation: Methylation is key to keeping your DNA in shape and regulating which genes are active.
  • Hormone Balance: Methylation helps keep hormones like testosterone in check.
  • Energy Production: It plays a big role in producing the energy your cells need to thrive.
  • Immune Function: Methylation supports a healthy immune system and helps with inflammation.
  • Heart Health: It helps maintain healthy homocysteine levels, which protect your heart.
  • Brain Function: Methylation impacts the production of neurotransmitters like serotonin and dopamine, which affect your mood and mental clarity.

What is Methylation Testing? How Does it Help with Healthy Aging?

Methylation testing gives you insight into how well your body is performing this important process. By analyzing a small sample of your blood or saliva, the test can determine if you have any genetic variants (like MTHFR) that affect your ability to properly methylate.

Umaro pointed out that roughly 44% of people have an MTHFR gene variant that can slow down methylation. This variant can lower the body’s ability to process folate and convert it to its active form. When methylation slows down, it can lead to problems with detoxification, hormone balance, and even cardiovascular health——factors that are all essential for healthy aging.

With methylation testing, you can find out if you’re one of those people, and we can help you optimize your health based on the results.

How Do You Know If You Have Methylation Issues?

So, how do you know if your methylation process is off? It’s one of those things that can fly under the radar for a while. You might not realize there’s an issue until you start noticing small signs that your body isn’t functioning like it used to.

Methylation issues can manifest in many ways. Some of the most common signs of impaired methylation include:

  • Fatigue – Feeling sluggish or drained, even after a good night’s sleep.
  • Mood Swings or Anxiety – Struggling with mood or feeling on edge.
  • Brain Fog – Finding it hard to focus or remember things.
  • Hormonal Imbalances – Dealing with low libido, testosterone issues, or other hormone-related symptoms.
  • Detox Struggles – Sensitivity to toxins, whether from food, alcohol, or the environment.

If you’re noticing any of these signs, methylation testing can help you get to the bottom of what’s really going on in your body.

What Are the Benefits of Methylation Testing?

Methylation testing gives you the power to take control of your health in ways you might not have thought possible. For many people, it’s the key to optimizing energy, performance, and overall well-being. But it’s not just about fixing what’s broken—it’s about reaching your full potential.

When you get a methylation test, you’re getting a roadmap to how your body works and what it needs to function at its best. This means you can take steps to address issues before they become bigger problems, helping you feel better and age well.

Some of the top benefits of methylation testing include:

  • Personalized Health Insights – Learn how your body processes key nutrients and detoxifies toxins, so you can make informed choices.
  • Proactive Health Management – Address potential issues like cardiovascular problems or hormone imbalances before they become serious.
  • Optimized Supplementation – Target specific areas of need with a personalized supplement regimen tailored to your genetic makeup.
  • Boosted Energy and Vitality – Get the energy and focus you need by making sure your body is firing on all cylinders.
Victory Men's Health: Methylation Testing for Healthy Aging | Middle Aged Man Exercising

Who Should Take a Genetic Methylation Test?

You don’t need to have major health issues to benefit from a methylation test. In fact, this kind of testing is great for anyone who wants to get ahead of potential problems and make sure they’re doing everything they can to stay in peak condition.

Methylation testing is especially helpful for:

  1. Men and women with a family history of heart disease, autoimmune conditions, or cognitive decline. If these run in your family, you’ll want to know if you have genetic markers that put you at risk.
  1. Individuals struggling with unexplained fatigue, brain fog, or hormonal imbalances. If you’re not feeling like yourself, methylation could be part of the issue.
  1. Anyone who wants to be proactive about their health. Maybe you’re feeling good now, but you want to make sure you stay that way. Understanding your methylation process can help you stay sharp and strong as you age.

How Much Does a Genetic Methylation Test Cost?

The cost of a genetic methylation test can vary depending on what’s included and where you get it; whether it’s an at-home kit or an in-person visit to a functional medicine expert’s office. Typically, these tests range from $200 to $500, depending on the depth of the analysis and any additional panels included.

It’s a short-term investment that could pay off big-time when it comes to your long-term health, helping you take action now to avoid serious problems later.

Is a Methylation Test Worth It?

It depends on what you want to achieve. Full methylation testing can uncover various genetic mutations that might contribute to health issues, which is valuable for understanding potential genetic predispositions. However, if you’re after actionable insights, Spectracell micronutrient testing may be even more useful. 

Rather than just identifying genetic mutations, micronutrient testing shows whether you’re actually low in key nutrients like folate, B12, choline, or CoQ10, and if you have high homocysteine levels—a marker of inflammation linked to cardiovascular risk.

While methylation testing can reveal underlying genetic factors, micronutrient testing gives you practical information to act on. Ultimately, knowing your nutrient status and addressing any deficiencies can be the most direct way to improve energy, performance, and longevity.

Ways to Address Methylation Issues

If your methylation test shows some issues, don’t worry—there’s a lot you can do to address them. At Victory Men’s Health, we’ll work with you to create a personalized treatment plan designed to optimize your methylation and overall health. Some of the ways to address methylation issues include: 

  • Diet Adjustments – Adding more foods rich in folate and nutrients that support methylation.
  • Supplements – Using targeted supplements like methylfolate, B12, magnesium, or creatine to help your body function better.
  • Detox Support – Supporting your body’s natural detoxification process to help you feel more energized and focused.
  • Lifestyle Coaching – Simple tweaks to your daily routine, like managing stress and improving sleep, can go a long way in improving methylation.

Start Your Wellness Journey with Victory Men’s Health

Methylation testing is a powerful tool in your health arsenal, and we’re here to help you take full advantage of it. Whether you’re looking to improve your energy, balance your hormones, or just feel stronger overall, we can guide you toward personalized solutions that work for you. 

Ready to take the first step? Contact us today to schedule your consultation and begin the journey to better health, vitality, and well-being. 

Want to Learn More? Tune Into the Podcast!

For those interested in learning more, we invite you to check out the Women Want Strong Men podcast hosted by Amy Stuttle, the founder and CEO of Victory Men’s Health available on YouTube, Apple Podcasts, and Spotify.

If you live in Missouri or Illinois, taking the first step towards optimizing your hormones is easy with Victory Men’s Health. Whether through telehealth or in-person visits, our team is ready to develop a treatment plan that works for you.

Your first visit is $99, which includes a confidential consultation with one of our medical providers, PSA testing, testosterone assessment, body composition analysis, and a customized “test dose” of our proven medication if needed.