Can Hormone Replacement Therapy Increase Cancer Risk?

Tired of struggling with symptoms like irritability, sluggishness, and low libido? Considering hormone replacement therapy (HRT) but wondering, “can hormone replacement therapy increase cancer risk?” If this sounds like you, you’re not alone. 

For men dealing with low testosterone, HRT can be a game-changer in combating feelings of sluggishness, muscle weakness, and low motivation. For women, it often brings much-needed relief from menopause symptoms like hot flashes, night sweats, and irritability.

But with all its benefits, it’s natural to wonder about the risks. The possibility of cancer is a concern we commonly see come up in conversations about HRT. On an episode of the Women Want Strong Men podcast, we discussed all things hormone optimization with Dr. Jordan Grant, a subject matter expert. Check out the full episode, then keep reading for more. 

Today, we’re breaking down everything you need to know about the link between hormone replacement therapy and cancer risk. Ready to separate myth from reality? Let’s jump in.

What Is Hormone Replacement Therapy?

Hormone replacement therapy (HRT) is about more than just replacing one hormone—it’s about restoring balance to your entire hormonal system. Both men and women benefit from comprehensive hormone analysis to identify exactly what their bodies need. 

Hormones play a critical role in everything from energy and mood to libido and muscle strength, so optimizing these levels can help you feel like yourself again. Here’s a closer look at HRT for men and women:

  • Hormone Replacement Therapy for Men: While testosterone replacement therapy (TRT) is commonly discussed, men often need more than just testosterone. A personalized HRT plan might also address other hormones to ensure a complete approach to health and vitality. Testosterone can be delivered via injections, creams, or pellets, depending on individual needs.
  • Hormone Replacement Therapy for Women: Women often associate HRT with estrogen, but testosterone is just as important for overall well-being. A tailored HRT plan may include estrogen, progesterone, and testosterone to relieve menopause symptoms, boost energy, improve libido, and support mental clarity. These hormones can be administered through pills, patches, creams, or pellets.
  • Bioidentical Hormone Therapy (BHRT): Bioidentical hormones are the safest and most effective option because they closely mimic the hormones your body naturally produces. While some BHRT formulations are compounded for specific doses or to eliminate allergens, many are available through commercial pharmacies in forms like pills, troches, injections, topicals, and pellets.

Can Hormone Replacement Therapy Increase Cancer Risk?

The connection between HRT and cancer risk is one of the most debated topics in medicine. Certain cancers, like breast and prostate cancer, are hormone-sensitive, meaning they can grow in response to specific hormones. But does that mean HRT causes cancer? Not necessarily.

  • For Women: The type of hormones used in HRT matters. Studies show that synthetic progestins, like Provera, combined with estrogen, increase breast cancer risk. In contrast, bioidentical progesterone has a protective effect, counteracting estrogen’s impact on breast tissue and potentially reducing this risk. Choosing bioidentical hormones over synthetic options is a critical factor in ensuring safer, more effective HRT.
  • For Men: Testosterone Replacement Therapy (TRT) has often been linked to concerns about prostate cancer. However, many studies have dispelled this concern. One example is a major study published in European Urology, which found no evidence that TRT increases prostate cancer risk when appropriately managed.

The bottom line? While certain risks exist, they’re often small and highly dependent on factors like the type of therapy, dosage, duration, and your individual health history. That’s why personalized care and ongoing monitoring are essential.

Can I Reduce the Risk of Cancer on HRT?

If you’re worried about potential risks, you’re not alone. The good news is there are ways to minimize those risks while still reaping the benefits of HRT. This comes down to being informed, making smart choices about your lifestyle, and—most importantly—working with a healthcare provider who has your best interests at heart.

Certain factors can increase your cancer risk, like the type of hormones and administration method used, a family history of hormone-sensitive cancers, or an unhealthy lifestyle. That’s why it’s crucial to take a holistic approach to your health while on HRT. Here are some ways to lower your risk: 

  • Stick to a personalized treatment plan designed just for you.
  • Commit to regular screenings, such as mammograms or prostate exams.
  • Focus on a healthy diet, exercise, and quitting harmful habits like smoking.

What are the Benefits of HRT?

Now, let’s talk about the upside. It’s no exaggeration to say HRT can change your life. Imagine waking up energized, focused, and ready to tackle the day. That’s the power of balanced hormones. Here’s a look at some of the key benefits of HRT for men and women. 

  • For Men: HRT can improve muscle strength, sharpen mental clarity, boost libido, and restore energy levels.
  • For Women: HRT helps relieve menopause symptoms like hot flashes, supports bone health, improves sleep, and enhances mood.

Beyond the physical benefits, here’s what’s even more important: quality of life and physiological benefits. HRT can help to improve bone mineral density, insulin sensitivity, and cardiovascular health. It can also help you feel more connected to yourself and the people around you, empowering you to live life to its fullest. 

Our Approach to Hormone Replacement Therapy

We don’t believe in one-size-fits-all solutions. Your hormone needs are as unique as you are, and that’s why we take a personalized approach to HRT. Our approach starts with comprehensive lab testing to get a deep understanding of your hormone levels and health. 

From there, we design a customized treatment plan tailored to your symptoms, lifestyle, and goals. But our support doesn’t stop there—ongoing monitoring is a cornerstone of our care. Regular bloodwork and follow-ups ensure your therapy remains safe and effective. 

We also prioritize educating our clients, because the more you understand about your health, the more empowered you’ll feel to take charge of it. From start to finish, we’re here to support you every step of the way. 

Questions Our Patients Ask About HRT and Cancer Risk

Does HRT Cause Cancer?

No. HRT itself doesn’t cause cancer, but it can influence hormone-sensitive cancers in specific cases. Proper monitoring and individualized care minimize this risk, especially if you have a history of certain cancers. 

Are Certain Types of HRT Riskier Than Others?

Yes, certain medications that are synthetic versions of hormones carry higher risks. At Victory Men’s Health, we use precise, evidence-based dosing to ensure safety.

How Often Should You Get Screened While on HRT?

Your screening frequency depends on the focus. For cancer, men should get an annual PSA test, while women need mammograms every 2 years and PAP tests every 3-5 years. For hormone monitoring, follow-ups are every 3-4 months at first, then annually once levels stabilize. Regular check-ups ensure safety and effectiveness.

Can You Reduce Cancer Risk While on HRT?

Absolutely. By working with a knowledgeable provider, sticking to personalized treatment plans, and leading a healthy lifestyle, you can keep your risks low.

What Is the Safest Hormone Replacement Therapy?

The safest HRT is one that’s personalized, based on previous medical and family history, and closely monitored.

Reclaim Your Health With Confidence

Hormone Replacement Therapy is a powerful tool for reclaiming your health and energy, but like anything, it should be approached thoughtfully. The risks are real, but they’re also manageable when you partner with a healthcare provider with proven experience in hormone health.


At Victory Men’s Health, we prioritize your safety, well-being, and long-term success. Ready to explore how HRT can make a difference in your life? Contact us today to schedule a consultation and take the first step toward feeling like yourself again.

Hormone Replacement Therapy for Men vs. Women

hormone replacement therapy - man walking into Victory Men's Health clinic

Hormones impact nearly every aspect of our lives, from energy and mood to sleep and relationships. When our hormone levels drop, the effects can leave us feeling like a shadow of ourselves. The good news? Hormone replacement therapy (HRT) for men and women offers a powerful way to restore balance and help you feel confident again.

On a recent episode of the Women Want Strong Men podcast, we discussed all things HRT with Anna Griffith, DNP, diving into the unique challenges men and women face as their hormones change. Check out the full episode below, then keep reading to learn more. 

Whether it’s testosterone therapy for men battling low libido or hormone optimization for women navigating menopause, HRT offers tailored solutions to help both sexes thrive. In this blog post, we’ll explore the key differences between hormone replacement therapy for men vs. women. From benefits to side effects and how to get started, we’re covering it all. Let’s dive in. 

What Is Hormone Replacement Therapy (HRT)?

Hormone replacement therapy (HRT) is a treatment designed to replenish hormones that have naturally declined due to aging, stress, or other factors. It’s not just fixing a few symptoms—HRT is a comprehensive approach to optimizing your health and well-being.

For Men: HRT typically focuses on testosterone replacement therapy (TRT), which addresses declining testosterone levels associated with aging. However, this can also include DHEA, pregnenolone, and possibly thyroid medication or melatonin. 

For Women: HRT often involves a combination of hormones like estrogen, progesterone, testosterone, thyroid, DHEA, pregnenolone, and melatonin (some or all of them) to manage the effects of menopause and hormonal imbalances.

While both men and women can benefit from HRT, the treatment protocols for each differ because of their unique hormonal systems. 

Why Do Men and Women Need HRT?

As we age, many of us chalk up feeling tired, moody, or “off” to just getting older. But what if there’s more to it? For both men and women, declining hormone levels can quietly wreak havoc on our energy, mood, sleep, and even relationships. 

You might notice changes like struggling to keep up with the kids, losing motivation at work, or feeling less confident in your own skin. Hormone replacement therapy (HRT) isn’t about reversing the clock, but restoring balance so you can feel stronger and more like yourself again.

HRT For Men

Testosterone levels naturally decline as men age, a process often referred to as andropause. By the time men hit their 40s or 50s, they may experience symptoms like:

  • Fatigue and low energy
  • Reduced libido and sexual performance
  • Muscle loss and difficulty building strength
  • Mood swings, irritability, or feelings of depression

For many men, HRT is the solution to restoring energy, improving physical performance, and reigniting confidence.

HRT For Women

For women, hormonal changes are often more dramatic, especially during perimenopause and menopause. The decline in estrogen and progesterone can lead to symptoms like:

  • Hot flashes and night sweats
  • Sleep disturbances and fatigue
  • Mood swings and anxiety
  • Vaginal dryness and reduced libido
  • Increased risk of osteoporosis and cardiovascular disease

HRT helps women regain control by addressing these symptoms and providing long-term health benefits, such as bone protection and cardiovascular health support.

What Are the Differences Between HRT for Men and Women?

Hormone replacement therapy isn’t one-size-fits-all, and that’s a good thing. Men and women experience different hormonal shifts, which means their treatment plans should reflect their unique needs.

The beauty of HRT is that it’s customizable. 

Whether it’s a man regaining his physical edge or a woman finding relief from relentless hot flashes, each journey is tailored to the individual. Let’s take a look at the key differences between hormone replacement therapy for men vs. women.

Hormones Involved

  • Men: Testosterone replacement therapy (TRT) is the primary focus, aiming to restore testosterone levels. However, you should work with a provider who tests and addresses all hormones—not just one. 
  • Women: Women often require a combination of hormones, including estrogen, progesterone, and testosterone, depending on their symptoms and needs.

Treatment Goals

  • For Men: The main objectives are boosted energy, libido, mental clarity, improved metabolism for muscle growth and fat loss, reduced risk of diabetes, bone health, and improved cognition. 
  • For Women: The goals are generally to alleviate menopause symptoms (e.g., hot flashes, mood swings, and painful intercourse), improve bone density, boost metabolism, improve sex drive, reduce the likelihood of cardiovascular disease and dementia, and protect long-term health. 

Delivery Methods

  • Men: Options include injections, gels, creams, pellets, or pills.
  • Women: Women may use patches, creams, pills, or injections, often in specific combinations tailored to their unique health needs.

Monitoring and Dosage

  • Men: Regular comprehensive lab tests, including complete blood counts, prostate-specific antigen (PSA), and a full hormone panel, are essential to ensure safe and effective testosterone treatment.
  • Women: Monitoring focuses on balancing multiple hormones for optimal benefit to symptoms and long-term health, and adjusting dosages or delivery form if side effects like bleeding or breast tenderness occur.

What Are the Benefits of Hormone Replacement Therapy?

The benefits of HRT can give people their lives back. For men, it can mean having the energy to hit the gym again or the confidence to reconnect with their partner. For women, it’s often about regaining peace of mind and feeling comfortable in their own skin. 

Whatever the need, HRT offers a path to feeling stronger, healthier, and more like the best version of yourself. Here are the benefits of hormone replacement therapy to consider: 

Benefits for Men

  • Increased energy and stamina
  • Enhanced libido and sexual performance
  • Improved muscle mass and strength
  • Better focus and mental clarity
  • Reduced risk of cardiovascular disease

Benefits for Women

  • Relief from hot flashes and night sweats
  • Improved mood and reduced anxiety
  • Better sleep quality
  • Increased bone density and reduced osteoporosis risk
  • Enhanced sexual health, including reduced vaginal dryness and improved libido

HRT Side Effects for Men vs. Women

Like any medical treatment, HRT comes with potential side effects. With a careful approach and ongoing guidance, side effects are usually mild and temporary. Working with a knowledgeable healthcare provider makes all the difference in turning potential challenges into manageable adjustments. Here are the possible side effects to be aware of. 

For Men 

  • Acne or oily skin
  • Increased red blood cell count 
  • Mild fluid retention
  • Decreased fertility

For Women 

  • Breast tenderness
  • Slight increased risk of blood clots (depending on the form administered and the patient’s risk factors) 
  • Spotting or irregular bleeding during adjustment periods

Questions Our Patients Ask About HRT for Men and Women

Does TRT Cause Cancer?

No, there’s no evidence that testosterone replacement therapy (TRT) causes cancer. 

Is HRT Only for Menopause?

No, HRT isn’t just for menopause. Women may need HRT for other hormonal imbalances, and men benefit from HRT at various life stages.

How Do I Know If I Need HRT?

If you’re experiencing symptoms like fatigue, mood swings, or decreased libido, a hormone test and consultation can determine whether hormone replacement therapy is right for you.

Is Hormone Replacement Therapy Safe?

Yes, when administered and monitored by a qualified provider, HRT is safe and effective for men and women with a hormonal imbalance. 

How Long Does it Take for HRT to Work?

Most people notice improvements within a few weeks, but experiencing the full range of benefits may take several months as your hormone levels stabilize.

Where Can I Go For HRT?

Victory Men’s Health! We specialize in hormone optimization and offer personalized treatment plans tailored to your unique lifestyle, needs, and goals.

Take the First Step Toward Feeling Your Best

Hormone replacement therapy is about restoring your confidence, vitality, and quality of life. Whether you’re a man looking to regain energy and muscle strength or a woman seeking relief from menopause symptoms, HRT can make a big difference.


At Victory Men’s Health, we understand that every individual is unique, and we’re here to create a treatment plan that works for you. Ready to take the next step? Contact us today to schedule your consultation and start feeling like yourself again.